Fisetin

About Fisetin

Fisetin is a flavonol, a type of flavonoid polyphenol, with the chemical name 3,3,4,7 tetrahydroxyflavone. It was historically obtained from young fustic, the wood of the smoke tree Cotinus coggygria, which was used as a yellow dye. In the diet it occurs in apples, persimmons, grapes, onions, and cucumbers, with strawberries among the richest known sources. Fisetin has attracted interest as a senolytic, a compound that selectively promotes the death of senescent cells, which accumulate with age and secrete inflammatory factors linked to age related disease. In a 2018 study, Mayo Clinic researchers screened a panel of flavonoids, reported fisetin as the most potent senolytic among them, and found that it reduced senescence markers and extended lifespan in mice. Clinical trials in humans are under way, including in frailty and kidney disease, but no clinical benefit has yet been established. Preclinical work also describes antioxidant and neuroprotective effects. Fisetin is poorly soluble in water and rapidly metabolized, which limits its bioavailability.