Conjugated Linoleic Acid CLA
About Conjugated Linoleic Acid CLA
Conjugated linoleic acid refers to a family of isomers of linoleic acid in which two double bonds are separated by a single bond rather than by a methylene group. In nature it is produced mainly by bacteria in the rumen of cattle, sheep and goats, so meat and dairy fat from these animals are the main dietary sources, with grass fed animals tending to have higher levels. The predominant natural form is rumenic acid, the cis 9 trans 11 isomer, while supplements are usually made from vegetable oils and contain a mixture with the trans 10 cis 12 isomer. Animal studies suggested effects on body fat, immune function and tumor growth, which led to CLA being marketed as a weight loss supplement. Human trials have generally shown small or inconsistent changes in body composition, and some studies raised concerns that the trans 10 cis 12 isomer may adversely affect insulin sensitivity and blood lipids. Evidence for meaningful health benefits remains limited.
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